In Mexico City there is a carving from the altarpiece of the Church of Santiago Tlatelolco showing him as Santiago Mataindios - the Indian-slayer.
And although Christianity and the Catholic religion were taken to the Americas by the Spaniards, when Mexico fought to obtain its independence from Spain in 1810, Sant’ Iago was exalted as Santiago Mataespañois - the slayer of Spaniards!
In Peru, during an indigenous uprising in 19th-century they adopted Santiagoas its champion, using the "Matamoros" iconography of “Santiago Mataespañois” that in Peru had come to be associated with a pre-Columbian deity who drove out evil forces. There is a mid-19thC silver statue of Santiago Mataespañois in the Museum of Pilgrimages in Santiago de Compostela.
and another one – scroll down to under Ano 1998 - (as well as pictures of items from the museum) here:
You can see the altarpiece of Santiago Mataindios here (click on the photo to enlarge it)
You can see paintings of Santiago Matamoros and Mataindios together here: